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The Offset Printing Process
The most simple explanation of the offset printing process that I have come across is from Understanding Desktop Color by Michael Kieran, published by Peachpit Press © in 1994.

Offset lithography is a printing process whereby the image that is to be printed is chemically etched into a paper or metal plate, inked and offset from the plate to a rubber blanket, and then printed from the blanket to the paper. This is done because paper will mar the surface of the plate after a few thousand impressions.

The image areas on the litho plate attract grease and repel water, while the non-printing areas attract water and repel grease. On press, the plate contacts the rollers that have been wet by dampening solution, then the rollers wet by ink.

The non-image areas pick up the dampening solution and repel ink. The image areas are are coated with ink, which is offset onto the rubber impression blanket cylinder. The ink is transferred to the paper as it passes between the blanket cylinder and the impression cylinder.

The result—a major advantage of the offset method—is that the soft rubber surface of the blanket creates a crisp impression on a variety of papers and other surfaces, both rough and smooth.

Each color that is to be printed requires a separate plate and impression pass through the press.
Because the process is offset, the original image must be first output as a negative (film), then etched onto the plate as a positive and offset as a negative to the blanket cylinder, then printed onto the paper as a positive.

There are two different ways in which paper is fed into a press: sheet-fed and web.

Sheet-fed: Paper is cut into individual sheets prior to printing. Most sheet-fed presses can print only one side of the sheet at a time, although perfecting presses, or perfectors, can print on both sides simultaneously.

The most popular sheet-fed presses have five or six inking stations that can print up to five or six colors and varnishes in one pass. Sheet-fed presses tend to make for crisper images and are used for everything from one-color business cards to fancy annual reports.

Web: Paper is supplied to the press in large reels, and both sides are usually printed at the same time. Web printing takes longer for make-ready (press preparation) and is typically used only on larger jobs (50,000 impressions or more), such as newspapers, magazines, catalogs, and direct mail pieces. Some presses even have sophisticated binding and trimming modules at the back end, capable of taking 12 or more 32-page signatures and folding, trimming, and gluing or stapling them into finished magazines.

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